Pharmaceutical Revatio Viagra Raw Material 99% Sildenafil Citrate Powder CAS 171599-83-0
What is Sildenafil Citrate?
Sildenafil is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension (PAH). Sildenafil elevates levels of the second messenger, cGMP, by inhibiting its breakdown via phosphodiesterase type 5 (PDE5). PDE5 is found in particularly high concentrations in the corpus cavernosum, erectile tissue of the penis. It is also found in the retina and vascular endothelium. Increased cGMP results in vasodilation which facilitates generation and maintenance of an erection. The vasodilatory effects of sildenafil also help reduce symptoms of PAH.
1.99% High Purity Sex Powder Sildenafil and Sildenafile Citrate
2. White crystal powder
3. Assay: 99.8%
4. Competitive price and fast delivery
5.Other name:Viagra
Chemical structure:
Applications
For the treatment of erectile dysfunction and to relieve symptoms of pulmonary arterial hypertension (PAH).
Associated Conditons
Erectile Dysfunction (ED)
NYHA Functional Class II-III Pulmonary arterial hypertension
Targets
1. cGMP-specific 3',5'-cyclic phosphodiesterase
2. Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
3. Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Enzymes
1. Cytochrome P450 3A4
2. Cytochrome P450 3A5
3. Cytochrome P450 3A7
4. Cytochrome P450 2C9
5. Cytochrome P450 2C19
6. Cytochrome P450 2D6
7. Cytochrome P450
8. Cytochrome P450 2E1
Chemical Specification of Sildenafil Citrate Powder
| ITEMS |
SPECIFICATIONS |
RESULTS |
| Appearance |
White or almost white crystalline powder |
White crystalline powder |
| Solubility |
Diffluent in ach, slightly soluble in methanol, almost insoluble in chloroform |
Complies |
| Identification HPLC |
Comply with standard |
Complies |
| IR |
IR should comply with the reference standard spectrum |
Complies |
| Citrate |
Positive |
Complies |
| Loss on drying |
≤1.0% |
0.35% |
| Acidity |
3.0-5.0 |
3.78 |
| Residue on ignition |
≤0.1% |
0.07% |
| Heavy metals |
≤20ppm |
Complies |
| Relevant impurity |
≤0.5% |
0.028% |
| Methanol |
≤0.3% |
0.02% |
| Methylene dichloride |
≤0.06% |
0.017% |
| N,N-Dimethyl formamide |
≤0.088% |
Not detected |
| Assay(on dried basis) |
≥99.5% |
99.89% |
Syntheses Material intermediates, pharmaceutical intermediates.
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